MOTS-c
MOTS-c is a mitochondrial function peptide used in evidence-based, physician-supervised protocols. Use for metabolic optimization, insulin sensitization, exercise enhancement, and longevity.
What is MOTS-c?
Mitochondria-derived peptide from mitochondrial 12S rRNA. Translocates to nucleus under metabolic stress, activates AMPK and the FOXO/SIRT1 pathway, upregulates glucose and fatty acid metabolism genes. Acts as exercise mimetic at nuclear gene regulation level. T2DM application: 1mg EOD to lower blood glucose.
Uses & clinical decision logic
Use for metabolic optimization, insulin sensitization, exercise enhancement, and longevity. 3x/year cycles (every 5 days x 20 days = 4 injections/cycle).
MOTS-c dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 10mg | 1mL | 5-10mg | 50-100 units | Every 5 days x 20 days | SubQ |
| 40mg | 4mL | 5-10mg | 50-100 units | Every 5 days x 20 days | SubQ |
Safety & contraindications
Dosing in T2DM (1mg) significantly lower than performance dosing — do not conflate.
Stacking & combinations
Sequence after SS-31 for maximum mitochondrial effect; synergistic with AICAR and NAD+.
Related peptides
Frequently asked questions
What is MOTS-c used for?
Use for metabolic optimization, insulin sensitization, exercise enhancement, and longevity. 3x/year cycles (every 5 days x 20 days = 4 injections/cycle).
What is the typical MOTS-c dosage?
Common dosing ranges from 5-10mg (Every 5 days x 20 days, SubQ). Exact dosing is individualized and set by a licensed physician.
How is MOTS-c administered?
MOTS-c is typically administered via SubQ.
What are the contraindications for MOTS-c?
Dosing in T2DM (1mg) significantly lower than performance dosing — do not conflate.
Build a physician-supervised protocol around your goal — no gatekeeping, real doctors, 503A compounding pharmacies.
Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.