AICAR
AICAR is a mitochondrial function peptide used in evidence-based, physician-supervised protocols. Use for metabolic syndrome, insulin resistance, weight loss augmentation, exercise performance, or as mitochondrial activator during sedentary phases.
What is AICAR?
5-Aminoimidazole-4-carboxamide ribonucleoside. Metabolized to ZMP, a direct AMP-kinase (AMPK) activator. AMPK activation mimics exercise effects: increases mitochondrial biogenesis, fatty acid oxidation, glucose uptake, and GLUT4 expression. Exercise mimetic. Run 2-4 cycles/year (5-10 days each).
Uses & clinical decision logic
Use for metabolic syndrome, insulin resistance, weight loss augmentation, exercise performance, or as mitochondrial activator during sedentary phases.
AICAR dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 50mg | 5mL | 5-10mg | 50-100 units | 5-10 days per cycle | SubQ |
Safety & contraindications
May cause hypoglycemia — monitor glucose, especially in diabetics. Do not combine with metformin (both AMPK activators — additive hypoglycemia risk).
Stacking & combinations
Synergistic with MOTS-c and SS-31 for comprehensive mitochondrial protocol; pairs with SLU-PP-332.
Related peptides
Frequently asked questions
What is AICAR used for?
Use for metabolic syndrome, insulin resistance, weight loss augmentation, exercise performance, or as mitochondrial activator during sedentary phases.
What is the typical AICAR dosage?
Common dosing ranges from 5-10mg (5-10 days per cycle, SubQ). Exact dosing is individualized and set by a licensed physician.
How is AICAR administered?
AICAR is typically administered via SubQ.
What are the contraindications for AICAR?
May cause hypoglycemia — monitor glucose, especially in diabetics. Do not combine with metformin (both AMPK activators — additive hypoglycemia risk).
Build a physician-supervised protocol around your goal — no gatekeeping, real doctors, 503A compounding pharmacies.
Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.