Semaglutide (GLP-1)
Semaglutide (GLP-1) is a weight management peptide used in evidence-based, physician-supervised protocols. Standard-of-care first-line weight management.
What is Semaglutide (GLP-1)?
GLP-1 receptor agonist. Reduces appetite via hypothalamic GLP-1R, slows gastric emptying, potentiates glucose-stimulated insulin secretion, reduces glucagon, promotes satiety. FDA-approved for T2DM and obesity. TITRATION: Start 250mcg (5 units) weekly; increase by 250mcg every 4 weeks as tolerated to target 1-2.5mg. Inject same day each week.
Uses & clinical decision logic
Standard-of-care first-line weight management. Choose based on patient tolerance — longer titration for GI-sensitive patients.
Semaglutide (GLP-1) dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 5mg | 1mL | 250mcg-2.5mg (titrate) | 5-50 units | 1x/week | SubQ |
| 10mg | 2mL | 250mcg-2.5mg (titrate) | 5-50 units | 1x/week | SubQ |
| 30mg | 3mL | 250mcg-2.5mg (titrate) | 2.5-25 units | 1x/week | SubQ |
Safety & contraindications
Pancreatitis history, personal/family history MEN2 or MTC, pregnancy. Monitor for GI side effects, especially early.
Stacking & combinations
Can add Cagrilintide for additive satiety; compatible with AOD-9604 and metabolic peptides.
Related peptides
Frequently asked questions
What is Semaglutide (GLP-1) used for?
Standard-of-care first-line weight management. Choose based on patient tolerance — longer titration for GI-sensitive patients.
What is the typical Semaglutide (GLP-1) dosage?
Common dosing ranges from 250mcg-2.5mg (titrate) (1x/week, SubQ). Exact dosing is individualized and set by a licensed physician.
How is Semaglutide (GLP-1) administered?
Semaglutide (GLP-1) is typically administered via SubQ.
What are the contraindications for Semaglutide (GLP-1)?
Pancreatitis history, personal/family history MEN2 or MTC, pregnancy. Monitor for GI side effects, especially early.
Build a physician-supervised protocol around your goal — no gatekeeping, real doctors, 503A compounding pharmacies.
Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.