Tirzepatide (GLP-1/GIP)
Tirzepatide (GLP-1/GIP) is a weight management peptide used in evidence-based, physician-supervised protocols. Preferred over semaglutide when maximum weight loss is priority or semaglutide plateau is reached.
What is Tirzepatide (GLP-1/GIP)?
Dual GLP-1/GIP receptor agonist (twincretin). GIP activation amplifies GLP-1 effects on insulin secretion and adds direct adipocyte lipolysis via GIP receptors on fat cells. Produces superior weight loss vs. GLP-1 monotherapy (~20% SURMOUNT data). TITRATION: Start 2.5mg (25 units) x4 weeks → 5mg → 7.5mg → 10mg → 12.5mg → 15mg.
Uses & clinical decision logic
Preferred over semaglutide when maximum weight loss is priority or semaglutide plateau is reached.
Tirzepatide (GLP-1/GIP) dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 5mg | 0.5mL | 2.5-15mg (titrate) | 25-150 units | 1x/week | SubQ |
| 10mg | 1mL | 2.5-15mg (titrate) | 25-150 units | 1x/week | SubQ |
| 15mg | 1mL | 2.5-15mg (titrate) | 17-100 units | 1x/week | SubQ |
| 30mg | 2mL | 2.5-15mg (titrate) | 17-100 units | 1x/week | SubQ |
| 60mg | 2mL | 2.5-15mg (titrate) | 8-50 units | 1x/week | SubQ |
Safety & contraindications
Same as GLP-1 class — MEN2, MTC, pancreatitis.
Stacking & combinations
Can add Cagrilintide, AOD-9604, or metabolic peptides. Do not combine with semaglutide.
Related peptides
Frequently asked questions
What is Tirzepatide (GLP-1/GIP) used for?
Preferred over semaglutide when maximum weight loss is priority or semaglutide plateau is reached.
What is the typical Tirzepatide (GLP-1/GIP) dosage?
Common dosing ranges from 2.5-15mg (titrate) (1x/week, SubQ). Exact dosing is individualized and set by a licensed physician.
How is Tirzepatide (GLP-1/GIP) administered?
Tirzepatide (GLP-1/GIP) is typically administered via SubQ.
What are the contraindications for Tirzepatide (GLP-1/GIP)?
Same as GLP-1 class — MEN2, MTC, pancreatitis.
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Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.