Retatrutide (GLP-1/GIP/Glucagon)
Retatrutide (GLP-1/GIP/Glucagon) is a weight management peptide used in evidence-based, physician-supervised protocols. Use when maximum weight loss is needed, especially in patients with fatty liver (GcgR drives hepatic fat clearance).
What is Retatrutide (GLP-1/GIP/Glucagon)?
Triple receptor agonist (triagonist) — GLP-1R, GIPR, and GcgR activation. Glucagon receptor activation adds hepatic fat oxidation, thermogenesis, and energy expenditure on top of GLP-1/GIP satiety effects. Clinical data shows ~24% weight loss.
Uses & clinical decision logic
Use when maximum weight loss is needed, especially in patients with fatty liver (GcgR drives hepatic fat clearance). Reported to cause less brain fog and more energy than pure GLP-1 agents. Start 2mg.
Retatrutide (GLP-1/GIP/Glucagon) dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 5mg | 0.5mL | 2-12mg (titrate) | 20-120 units | 1x/week | SubQ |
| 10mg | 1mL | 2-12mg (titrate) | 20-120 units | 1x/week | SubQ |
| 30mg | 2mL | 2-12mg (titrate) | 13-80 units | 1x/week | SubQ |
| 60mg | 2mL | 2-12mg (titrate) | 7-40 units | 1x/week | SubQ |
Safety & contraindications
Glucagon component may transiently raise blood glucose — monitor in diabetics. Same class contraindications (MEN2, MTC, pancreatitis).
Stacking & combinations
Can combine with AOD-9604 or 5-Amino-1MQ for additional mechanisms.
Related peptides
Frequently asked questions
What is Retatrutide (GLP-1/GIP/Glucagon) used for?
Use when maximum weight loss is needed, especially in patients with fatty liver (GcgR drives hepatic fat clearance). Reported to cause less brain fog and more energy than pure GLP-1 agents. Start 2mg.
What is the typical Retatrutide (GLP-1/GIP/Glucagon) dosage?
Common dosing ranges from 2-12mg (titrate) (1x/week, SubQ). Exact dosing is individualized and set by a licensed physician.
How is Retatrutide (GLP-1/GIP/Glucagon) administered?
Retatrutide (GLP-1/GIP/Glucagon) is typically administered via SubQ.
What are the contraindications for Retatrutide (GLP-1/GIP/Glucagon)?
Glucagon component may transiently raise blood glucose — monitor in diabetics. Same class contraindications (MEN2, MTC, pancreatitis).
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Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.