PE-22-28 (Spadin Analog)
PE-22-28 (Spadin Analog) is a brain + mood peptide used in evidence-based, physician-supervised protocols. Use for depression, mood dysregulation, or as adjunct to SSRI therapy.
What is PE-22-28 (Spadin Analog)?
Spadin analogue — selective TREK-1 potassium channel blocker. TREK-1 inhibition produces rapid antidepressant effect (faster onset than SSRIs) via serotonin system normalization. Morning dosing required — avoid evening. Start 50mcg; titrate to 100-200mcg; ceiling 600mcg for treatment-resistant cases.
Uses & clinical decision logic
Use for depression, mood dysregulation, or as adjunct to SSRI therapy. Faster-acting than conventional antidepressants.
PE-22-28 (Spadin Analog) dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 10mg | 2mL | 50-200mcg | 1-4 units | Daily (5 on / 2 off) | SubQ |
Safety & contraindications
Avoid PM dosing — may cause insomnia. Start very low (50mcg). Long-term data limited.
Stacking & combinations
Synergistic with Selank (different mechanism, complementary mood support), Semax (BDNF-mediated), Dihexa.
Related peptides
Frequently asked questions
What is PE-22-28 (Spadin Analog) used for?
Use for depression, mood dysregulation, or as adjunct to SSRI therapy. Faster-acting than conventional antidepressants.
What is the typical PE-22-28 (Spadin Analog) dosage?
Common dosing ranges from 50-200mcg (Daily (5 on / 2 off), SubQ). Exact dosing is individualized and set by a licensed physician.
How is PE-22-28 (Spadin Analog) administered?
PE-22-28 (Spadin Analog) is typically administered via SubQ.
What are the contraindications for PE-22-28 (Spadin Analog)?
Avoid PM dosing — may cause insomnia. Start very low (50mcg). Long-term data limited.
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Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.