Melanotan-1 (Afamelanotide)
Melanotan-1 (Afamelanotide) is a melanin/skin peptide used in evidence-based, physician-supervised protocols. Use for photoprotection, tanning (aesthetic), and erythropoietic protoporphyria (FDA-approved in EU).
What is Melanotan-1 (Afamelanotide)?
Synthetic alpha-MSH analogue. Activates MC1R on melanocytes, driving melanin synthesis and increasing UV-induced melanogenesis. Safer profile than MT-II — does not activate MC3R/MC4R (no libido/erection effects). Loading phase: daily or EOD 2-4 weeks; maintenance: weekly.
Uses & clinical decision logic
Use for photoprotection, tanning (aesthetic), and erythropoietic protoporphyria (FDA-approved in EU).
Melanotan-1 (Afamelanotide) dosage & administration
| Vial size | BAC water | Dosing range | Units / dose | Frequency | Route |
|---|---|---|---|---|---|
| 10mg | 2mL | 250-500mcg | 5-10 units | Daily or EOD (loading), Weekly (maintenance) | SubQ |
Safety & contraindications
Nausea common at initiation — start low (250mcg). Monitor skin lesions — do not use with atypical moles without dermatology clearance.
Stacking & combinations
Compatible with skin peptides (GHK-Cu, SNAP-8).
Related peptides
Frequently asked questions
What is Melanotan-1 (Afamelanotide) used for?
Use for photoprotection, tanning (aesthetic), and erythropoietic protoporphyria (FDA-approved in EU).
What is the typical Melanotan-1 (Afamelanotide) dosage?
Common dosing ranges from 250-500mcg (Daily or EOD (loading), Weekly (maintenance), SubQ). Exact dosing is individualized and set by a licensed physician.
How is Melanotan-1 (Afamelanotide) administered?
Melanotan-1 (Afamelanotide) is typically administered via SubQ.
What are the contraindications for Melanotan-1 (Afamelanotide)?
Nausea common at initiation — start low (250mcg). Monitor skin lesions — do not use with atypical moles without dermatology clearance.
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Build your protocol →This page is for educational purposes only and is not medical advice. Peptide therapies described here are provided under physician supervision through 503A compounding pharmacies. Many peptides are not FDA-approved for the uses described. Do not start, stop, or change any protocol without consulting a licensed physician.